Modeling Neurological Disorders by Human Induced Pluripotent Stem Cells

Table 2

Summarizing the similarities and differences of ESC and iPSC for disease modeling.

	hESCs	iPSCs	Reference
Source	ICM	Adult somatic cell	[4, 15]
Basic pluripotent characteristics
Alkaline phosphatase activity	Yes	Yes	[4, 15]
Pluripotent genes expression	Yes	Yes	[4, 15]
Pluripotent cell surface markers	Yes	Yes	[4, 15]
In vitro and in vivo multilinage differentiation	Yes	Yes	[4, 15]
Transcriptomic expression	Normal pluripotent gene expression	Pluripotent gene expression but not all genes similar to hESCs and depend on reprogramming technique	[36, 100]
Proteomic expression	Normal proteomic expression	Not all proteomic expression identical to hESCs	[101]
Disease modeling	From PGD diagnosed embryo in IVF clinic	From diagnosed adult patient somatic cell	[88, 102]
Disease-related expression characteristic	Yes	Yes	[88, 102]