Review Article

Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription

Table 1

Transcription factors associated with sirtuins.

Sirtuin classSubstratePositionFunctionReference

K120Induction of cell cycle arrest[100]
p53K372Unknown[86]
K382Reduction of apoptosis[86, 101]
SIRT1HIF-1αK674Negative effect on tumor growth and angiogenesis[95]
FOXO1K242, K245 and K262
Not known
Transcriptional activation
Inhibition of FOXO1 activity
[102]
[103]
FOXO3aNot knownInduction of cell cycle arrest and resistance to oxidative stress; inhibition of FOXO-mediated induction of apoptosis; inhibition of FOXO transcriptional activity[104, 105]
E2F1Not knownInhibition of E2F1 transcriptional activity; inhibition of E2F1-mediated apoptosis[36]
NF-κBK310 of  RelA/p65 subunitInhibition of NF-κB transcriptional activity and prevention of the release of proinflammatory mediators[89]

Sir2αp53Not knownAttenuation of p53-mediated transcriptional activity Inhibition of p53-dependent apoptosis in response to DNA damage[106]

SIRT2FOXO3aNot knownDNA binding and activation of target genes[43, 107]

SIRT3AceCS2K642Activation of the acetyl-CoA synthetase activity of AceCS2[108, 109]

SIRT5PGC-1αNot knownUnknown[110]

SIRT6HIF-1αNot knownRegulation of glucose homeostasis. Reduction of glycolysis and increase of mitochondrial respiration[98]

SIRT6NF-κBNot knownReduction of NF-κB-mediated apoptosis and senescence[99]