BioMed Research International / 2011 / Article / Tab 1 / Review Article
Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription Table 1 Transcription factors associated with sirtuins.
Sirtuin class Substrate Position Function Reference K120 Induction of cell cycle arrest [100 ] p53 K372 Unknown [86 ] K382 Reduction of apoptosis [86 , 101 ] SIRT1 HIF-1α K674 Negative effect on tumor growth and angiogenesis [95 ] FOXO1 K242, K245 and K262 Not known Transcriptional activation Inhibition of FOXO1 activity [102 ] [103 ] FOXO3a Not known Induction of cell cycle arrest and resistance to oxidative stress; inhibition of FOXO-mediated induction of apoptosis; inhibition of FOXO transcriptional activity [104 , 105 ] E2F1 Not known Inhibition of E2F1 transcriptional activity; inhibition of E2F1-mediated apoptosis [36 ] NF-κ B K310 of RelA/p65 subunit Inhibition of NF-κ B transcriptional activity and prevention of the release of proinflammatory mediators [89 ] Sir2α p53 Not known Attenuation of p53-mediated transcriptional activity Inhibition of p53-dependent apoptosis in response to DNA damage [106 ] SIRT2 FOXO3a Not known DNA binding and activation of target genes [43 , 107 ] SIRT3 AceCS2 K642 Activation of the acetyl-CoA synthetase activity of AceCS2 [108 , 109 ] SIRT5 PGC-1α Not known Unknown [110 ] SIRT6 HIF-1α Not known Regulation of glucose homeostasis. Reduction of glycolysis and increase of mitochondrial respiration [98 ] SIRT6 NF-κ B Not known Reduction of NF-κ B-mediated apoptosis and senescence [99 ]