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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 379123, 7 pages
http://dx.doi.org/10.1155/2011/379123
Review Article

Clinical Cancer Therapy by NK Cells via Antibody-Dependent Cell-Mediated Cytotoxicity

1Department of Human Oncology, University of Wisconsin, Madison, WI 53705, USA
2Department of Pediatrics, University of Wisconsin, Madison, WI 53705, USA
3Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792-6164, USA

Received 1 February 2011; Accepted 16 March 2011

Academic Editor: Roberto Biassoni

Copyright © 2011 Kory L. Alderson and Paul M. Sondel. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Natural killer (NK) cells are powerful effector cells that can be directed to eliminate tumor cells through tumor-targeted monoclonal antibodies (mAbs). Some tumor-targeted mAbs have been successfully applied in the clinic and are included in the standard of care for certain malignancies. Strategies to augment the antitumor response by NK cells have led to an increased understanding of how to improve their effector responses. Next-generation reagents, such as molecularly modified mAbs and mAb-cytokine fusion proteins (immunocytokines, ICs) designed to augment NK-mediated killing, are showing promise in preclinical and some clinical settings. Continued research into the antitumor effects induced by NK cells and tumor-targeted mAbs suggests that additional intrinsic and extrinsic factors may influence the antitumor response. Therefore more research is needed that focuses on evaluating which NK cell and tumor criteria are best predictive of a clinical response and which combination immunotherapy regimens to pursue for distinct clinical settings.