Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes

Figure 4

Dynamic remodeling of the SR network of neonatal and adult ventricular myocyte. (a) Confocal image of a neonatal ventricular myocytes expressing tRFP-SR. Images to the left show expanded views of sites i and ii at various time points. The red arrow in site ii marks a corbular SR bouton. Redlines delineate a portion of the SR network and shows elongation and subsequent fusion of this SR bouton to an adjacent SR tubule. (b) Time-lapse confocal imaging of a region of an adult ventricular myocyte expressing tRFP-SR. Redlines delineate a portion of the SR network and shows elongation and subsequent fusion of SR tubule to an adjacent SR tubule. (c) Confocal image of an adult ventricular myocyte. Surface plots at multiple time points of sites i and ii are shown to the right of this image.