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Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 382586, 14 pages
Research Article

Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes

Department of Physiology & Biophysics, University of Washington, Box 357290, Seattle, WA 98195, USA

Received 29 April 2011; Accepted 9 August 2011

Academic Editor: Xupei Huang

Copyright © 2011 Amanda L. Vega et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Legends for Supplementary Movies:

  • Movie S1: A time-lapse confocal microscopy movie of a neonatal myocyte expressing tRFP-SR, that follows the movement of multiple corbular SR boutons for 300 seconds.

  • Movie S2: A Time-lapse confocal microscopy movie of site I from Figure 3A of the neonatal myocyte expressing tRFP-SR showing the dynamic remodeling of the SR network.

  • Movie S3: An animation of change in tRFP-SR fluorescence over a 10 minute period from an adult ventricular myocyte.

  • Movie S4: A time-lapse TIRF microscopy movie of changes in SR morphology within the sub-sarcolemmal space of a neonatal ventricular myocytes expressing tRFP-SR.

  • Movie S5: A time-lapse confocal microscopy movie of a neonatal myocyte expressing tRFP-SR labeled with BODIPY FL-X Ryanodine that follows the movements of multiple RyR labeled corbular SR boutons for 300 seconds.

  1. Supplementary Material