Figure 1: Oscillations in blood glucose levels in a representative diabetic (DM) BBDP rat treated with insulin pellets implanted subcutaneously. During a follow-up period of 140 days the DM BBDP rat received multiple insulin pellet implants (ips) guided by rapid development of hyperglycaemia (solid line) and drop in body weight (not shown). For comparison, glucose levels in an age-matched thymectomized non-DM BBDP rat are shown. The grey area indicates the normoglycaemic range (4–8 mmol/L).