HDAC Activity Is Required for Efficient Core Promoter Function at the Mouse Mammary Tumor Virus Promoter
Proposed model for the role of HDACs in basal transcription from the MMTV promoter. (a) HDACs remove acetyl groups from proteins that are part of the reinitiation scaffold. This may occur prior to binding to the template (as shown) or at the template. This deacetylation facilitates binding of RNA pol II and the initiation of transcription. When HDAC activity is inhibited through HDAC inhibitors, shown in (b) persistent acetylation of basal transcription machinery components does not destabilize the complex or prevent its assembly. However, the recruitment of RNA pol II is impaired, leading to a decrease in the rate of transcriptional initiation.