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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 419343, 8 pages
Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo
1PET-CT Center, The Affiliated Hospital of Inner Mongolia Medical College, TongDao North Street, Hohhot 010050, China
2Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical College, TongDao North Street, Hohhot 010050, China
3Department of Medical Education, The Affiliated People’s Hospital of Inner Mongolia Medical College, Zhaoruda Street, Hohhot 010010, China
Received 30 December 2010; Revised 22 March 2011; Accepted 4 April 2011
Academic Editor: David J. Yang
Copyright © 2011 Xuemei Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [45 citations]
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- Roger A. Close, and Emily J. Rayfield, “Functional Morphometric Analysis of the Furcula in Mesozoic Birds,” Plos One, vol. 7, no. 5, 2012.
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- Laura A. Solt, and Thomas P. Burris, “Action of RORs and their ligands in (patho)physiology,” Trends in Endocrinology & Metabolism, vol. 23, no. 12, pp. 619–627, 2012.
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- Bruno M. F. Gonçalves, Ana S. Leal, Yongkui Jing, Jorge A. R. Salvador, and Vânia M. Moreira, “Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs,” Natural Product Reports, vol. 29, no. 12, pp. 1463, 2012.
- Muthu K. Shanmugam, Xiaoyun Dai, Alan Prem Kumar, Benny K.H. Tan, Gautam Sethi, and Anupam Bishayee, “Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies,” Biochemical Pharmacology, vol. 85, no. 11, pp. 1579–1587, 2013.
- Yl Meng Yan-Ling, Bc Zheng Ben-Chang, Xc Wang Xu-Cheng, L Xiao Ling, and L Liu Liang, “Controlling the Shape of a Cold Atom Cloud in a Cylindrical Cavity,” Chinese Physics Letters, vol. 30, no. 6, 2013.
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- H. Y. Kim, “Ecological valuation in a transportation project: value transfer and spatial decision support systems,” International Journal of Environmental Science and Technology, vol. 11, no. 8, pp. 2281–2290, 2014.
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