Histone Deacetylase Inhibitors in the Treatment of Hematological Malignancies and Solid Tumors
The histone deacetylase, family. Schematic representations of class I (HDAC1, 2, 3, and 8), class II (HDAC4, 5, 6, 7, 9, and 10), class III (SIRT1), and class IV (HDAC11). Structure and Length of HDACs are shown. The total number of amino acid residues (aa) is depicted on the right, next to each HDAC. The enzymatic domains and the nucleus localization sequences are highlighted in brown and black, respectively.