Research Article
Development of Novel In Silico Model to Predict Corneal Permeability for Congeneric Drugs: A QSPR Approach
Table 2
Gradient mobile phase used during the analysis by HPLC-PDA for fluoroquinolones in group A and group B.
| Time (min) | Methanol (%) | Acetonitrile (%) | Buffer (20 mM) (%) | Flow rate (mL/min) |
|
Group A | |
| 0.01 | 0 | 10 | 90 | 1.0 | 4.00 | 5 | 15 | 85 | 1.0 | 10.0 | 0 | 40 | 60 | 1.0 | 12.0 | 0 | 10 | 90 | 1.0 |
|
Group B | |
| 0.01 | 10 | 10 | 80 | 1.0 | 6.00 | 10 | 10 | 80 | 1.0 | 8.00 | 0 | 50 | 50 | 1.0 | 10.0 | 10 | 10 | 80 | 1.0 |
|
|