Figure 7: Microvilli on the apical membrane of FS cells of WT and Nhe2-/- mice were similar morphologically. Electron micrographs of (a) WT and (b)–(d) Nhe2-/- FS cells. Arrowheads point to microvilli. Dense patches of tightly packed microvilli were occasionally seen in FS cell canaliculi in the null animals; in (b), the arrowhead lies in the center of one such canaliculus. Cytoplasmic vacuoles in the apical cytoplasm of FS cells sometimes had membranous inclusions, as indicated by the arrow in (c). C: canaliculus; N: nucleus; bars: 1 μm.