Therapeutic Strategies to Enhance the Anticancer Efficacy of Histone Deacetylase Inhibitors

<table>Activation of apoptosis by combinations of HDACi and ROS-generating agents. HDACi combined with agents like adaphostin and PEITC result in an increase production of ROS in cancer cells. The high levels of ROS result in induction of apoptosis via caspase activation.</table>

BioMed Research International

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Figure 2

Figure 2: Therapeutic Strategies to Enhance the Anticancer Efficacy of Histone Deacetylase Inhibitors 