Navigating the Human Metabolome for Biomarker Identification and Design of Pharmaceutical Molecules

Figure 5

Similarity network of indole. Pink nodes indicate human metabolites from HMDB and green nodes indicate natural compounds from CNPD. Node labels denote the respective ID codes of the compounds. The nodes are linked when the two compounds have 𝑇𝑐≥0.85. The width and color of the edges are analogous to the value of 𝑇𝑐: Cyan: 0.85≤𝑇𝑐<0.95, Black: 𝑇𝑐=1. The node in yellow denotes indole with HMDB ID and CAS registry number, respectively.