Review Article
Current Concepts: Mouse Models of Sjögren's Syndrome
Table 3
Features of common spontaneous and transgenic mouse models for SjS.
| Characteristic | Autoantibodies | Sjögren’s syndrome patient | Spontaneous mouse model | Transgenic mouse model | | NOD | Aec1Aec2 | NZB/ W F1 | MRL/ lpr | NFS/ sld | IQI/ Jic | Aly/ aly | HTLV-1 | BAFF | IL-6 | IL-10 | IL-12 | IL-14α |
| | Anti-Ro/SS-A, Anti-La/SS-B | Yes | Yes | No | No | Yes | Yes | No | — | — | No | — | No | Yes | Yes | | Anti-DNA (ANAs) | Yes | Yes | Yes | Yes | Yes | Yes | Yes | — | — | Yes | — | — | Yes | — | | Anti-α-fodrin | Yes | Yes | — | — | Yes | Yes | — | — | — | — | — | — | — | — | | Anti-β-adrenergic receptor | Yes | Yes | Yes | Yes | Yes | — | — | — | — | — | — | — | — | — | | Anti-type3 muscarinic Ach receptor | Yes | Yes | Yes | Yes | Yes | — | — | — | — | — | — | — | — | — |
| Leukocytic infiltrate | | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | - Time of onset (weeks) | | | 12 | 10 | 16 | 8 | 16 | 8 | 24 | 24 | 52 | 2 | 8 | <16 | 48 | Dacryoadenitis | | Yes | Yes | Yes | Yes | Yes | Yes | Yes | — | Yes | — | — | Yes | Yes | — | Sialadenitis | | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | — | Yes | Yes | Yes | Loss secretory function | | Yes | Var | Yes | Var | No | Yes | — | — | — | Yes | — | Yes | Var | Var | - Time of onset (weeks) | | | 20 | 19 | 24 | — | 72 | — | — | — | 52 | — | 8 | 16 | 12 | - Target organ | | | S, L | S, L | L | — | S, L | — | — | — | S | — | S, L | S, L | S | Proinflammatory cytokine product | | Yes | Yes | Yes | Yes | Yes | Yes | Yes | — | — | — | Yes | Yes | Yes | Yes |
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Var: variable, male, and female mice differ, –: Not determined, S: Salivary glands, L: Lacrimal glands.
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