Jun Dimerization Protein 2 Controls Senescence and Differentiation via Regulating Histone Modification
Figure 4
Model for the epigenetic regulation by JDP2. During the exposure of cells with oxydative stress, retinoic acid (RA), RANKL, TPA, and adipocyte inducing hormones, the histone H3, H4K8, and H4K16 as well as H3K27 were masked by JDP2 proteins and prevent the attack of histone modification enzymes like HAT (p300/CBP, pCAF, GCN5, MOF, etc.) and HMT (Ezh2 etc) in the cellular senescence and cell differentiation. This is a novel mechanism of JDP2 to inhibit the histone modification. The gene locus is either the p16Ink4a/Arf locus or C/EBPδ locus.
