Variability in Estrogen-Metabolizing Genes and Their Association
with Genomic Instability in Untreated Breast Cancer Patients and Healthy Women
Figure 2
Frequency of BCMN in untreated BC women and healthy controls considering the presence of estrogen-metabolizing genes polymorphisms (a) CYP17, (b) CYP1B1, (c) CYP1A1, and (d) COMT. A total of one thousand binucleated cells were analyzed for MN count in each of 62 BC patients and 62 age-matched controls. Bars represent standard error of mean; significantly different from the wild type in the control group; significantly different from the wild type in the patients group.
