Research Article

Variability in Estrogen-Metabolizing Genes and Their Association with Genomic Instability in Untreated Breast Cancer Patients and Healthy Women

Table 3

Frequency of micronucleated cells in untreated breast cancer women and controls with different genotypes.

GenotypeBreast cancer patients ( )Controls ( )P value
NumberCBMN ( )NumberCBMN ( )

CYP17
 TT27 38 <.0001
 TC+CC35 24 <.0001
CYP1B1
 Val/Val17 21 <.0001
 Val/Leu+Leu/Leu45 41 <.0001
CYP1A1
 TT40 53 <.0001
 TC+CC22 9 .001
COMT
 Val/Val21 34 .07
 Val/Met+Met/Met41 28 <.0001

MNF: micronucleus frequency; M: mean; SE: standard error; patients compared to controls.