Variability in Estrogen-Metabolizing Genes and Their Association with Genomic Instability in Untreated Breast Cancer Patients and Healthy Women

Table 4

Estrogen-metabolizing gene polymorphisms in breast cancer patients and controls with frequency of micronucleated cells higher than the mean of each group.

Genotype	Breast cancer patients (𝑛=27)		Controls (𝑛=26)		OR (95% CI)	P value
	Number	Frequency	Number	Frequency
CYP17
TT	12	0.44	9	0.35	1.0 (reference)	.57
TC+CC	15	0.56	17	0.65	0.6 (0.2–2.0)
CYP1B1
Val/Val	6	0.22	3	0.12	1.0 (reference)	.46
Val/Leu+Leu/Leu	21	0.78	23	0.88	0.46 (0.1–2.0)
CYP1A1
TT	21	0.78	16	0.62	1.0 (reference)	.2
TC+CC	6	0.22	10	0.38	0.4 (0.1–1.5)
COMT
Val/Val	6	0.22	13	0.5	1.0 (reference)	.04
Val/Met+Met/Met	21	0.78	13	0.5	3.5 (1–11.4)↑