Does Valproic Acid Induce Neuroendocrine Differentiation in Prostate Cancer?
Figure 4
Chromogranin A staining in prostate xenografts animals treated with or without VPA. (a): Representative images of CgA staining for xenograft sections from control and VPA-treated groups: LNCaP, C4-2, PC-3, and DU-145 (Scanned at 20X magnification using the APERIO imaging system). The tissue specimens of human pancreas and human prostate were positive internal controls for CGA staining, while another human prostate section served as a negative control. (b) Synaptophysin staining in prostate xenografts animals treated with or without VPA. A: Representative images of synaptophysin staining for xenograft sections from control and VPA-treated groups: LNCaP, C4-2, PC-3, and DU-145 (Scanned at 20X magnification using the APERIO imaging system). The tissue specimens of human pancreas and mouse colon were positive internal controls for synaptophysin staining, while mouse bladder as negative internal controls. (c) NCAM staining in prostate xenografts animals treated with or without VPA. (a): Representative images of CD56 staining for xenograft sections from control and VPA-treated groups: LNCaP, C4-2, PC-3, and DU-145 (scanned at 20X magnification using the APERIO imaging system). The tissue specimens of human colon carcinoid and normal human prostate were positive internal controls for NCAM staining, while mouse bladder was a negative control.
