Differential Effect of Calsequestrin Ablation on Structure and Function of Fast and Slow Skeletal Muscle Fibers

Figure 2

dCASQ-null male mice displayed a rate of spontaneous mortality even higher than that of CASQ1-null mice (see also [32]). Age-dependent survival analysis of male and female WT, CASQ1-null, and dCASQ-null mice housed under standard conditions evaluated using the Kaplan-Meier method. Number of animals included in the study: WT: male 𝑛=321, female 𝑛=318; CASQ1-null: male 𝑛=649, female 𝑛=632; dCASQ-null: male 𝑛=200, female 𝑛=222. As shown in Dainese et al. [32] male CASQ1-null mice were affected by a significantly increased rate of spontaneous mortality, particularly after 3 months of age: the additional ablation of CASQ2 worsened the phenotype.