Differential Effect of Calsequestrin Ablation on Structure and Function of Fast and Slow Skeletal Muscle Fibers
Ablation of CASQ1 and of both CASQ isoforms resulted in a significant reduction in body weight and grip strength test. (a) Ablation of CASQ1 and/or of both CASQ isoforms resulted in a significant reduction of body weight, which was more pronounced in dCASQ-null than in CASQ1-null mice (, 65, and 33 animals for WT, CASQ1-null, and dCASQ-null, resp.). (b) The evaluation of the maximal force that mice produced while grasping a bar (grip strength test, ) showed that the force output of CASQ1-null and dCASQ-null mice was significantly lower than that of WT animals, but not different from each other ( animals for WT, CASQ1-null, and dCASQ-null, resp.). Both body weight and grip strength test were measured in male mice. *Significantly different from WT.