BioMed Research International / 2011 / Article / Fig 3

Research Article

Differential Effect of Calsequestrin Ablation on Structure and Function of Fast and Slow Skeletal Muscle Fibers

Figure 3

Ablation of CASQ1 and of both CASQ isoforms resulted in a significant reduction in body weight and grip strength test. (a) Ablation of CASQ1 and/or of both CASQ isoforms resulted in a significant reduction of body weight, which was more pronounced in dCASQ-null than in CASQ1-null mice ( , 65, and 33 animals for WT, CASQ1-null, and dCASQ-null, resp.). (b) The evaluation of the maximal force that mice produced while grasping a bar (grip strength test, [33]) showed that the force output of CASQ1-null and dCASQ-null mice was significantly lower than that of WT animals, but not different from each other ( animals for WT, CASQ1-null, and dCASQ-null, resp.). Both body weight and grip strength test were measured in male mice. *Significantly different from WT.
634075.fig.003a
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634075.fig.003b
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