Synergistic Effects between Phosphorylation of Phospholamban and Troponin I Promote Relaxation at Higher Heart Rate

Figure 1

Cardiac output of isolated working hearts in the pacing and ISO treatment. All data are mean ± SEM. (a) Cardiac output of isolated working hearts in different rates of pacing. The 𝑛=6 hearts. *𝑃<0.05  versus  baseline. (b) Cardiac output in different concentrations of ISO treatment. The 𝑛=6 hearts in each ISO concentration. *𝑃<0.05 or **𝑃<0.01  versus  baseline. (c) The percentage increases in cardiac output in the heart rate increment of 60 beats/min. The 𝑛=6 hearts for each group. *𝑃<0.05  versus the pacing group. (d) The percentage increases in cardiac output at the pacing of 420 beats/min without and with ISO treatment. The 𝑛=6 hearts in each ISO concentration. *𝑃<0.05 or **𝑃<0.01  versus baseline.

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