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Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 678673, 8 pages
http://dx.doi.org/10.1155/2011/678673
Research Article

Antioxidant and Antinociceptive Effects of Citrus limon Essential Oil in Mice

1Departmento de Bioquímica e Farmacologia, Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Pesquisa em Neuroquímica Experimental, Núcleo de Tecnologia Farmacêutica, Universidade Federal do Piauí, Teresina, PI 64049-550, Brazil
2Departamento do Química, Centro de Ciências da Natureza, Universidade Federal do Piauí, Teresina, PI 64049-550, Brazil
3Laboratório de Análises Clínicas, Fortaleza, CE 60430-270, Brazil
4Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE 60430-270, Brazil
5Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Ceará, Fortaleza, CE 60430-140, Brazil

Received 17 November 2010; Revised 19 February 2011; Accepted 18 March 2011

Academic Editor: Dennis P. Murr

Copyright © 2011 Lidianne Mayra Lopes Campêlo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The antioxidant and antinociceptive activities of Citrus limon essential oil (EO) were assessed in mice or in vitro tests. EO possesses a strong antioxidant potential according to the scavenging assays. Moreover, it presented scavenger activity against all in vitro tests. Orally, EO (50, 100, and 150 mg/kg) significantly reduced the number of writhes, and, at highest doses, it reduced the number of paw licks. Whereas naloxone antagonized the antinociceptive action of EO (highest doses), this suggested, at least, the participation of the opioid system. Further studies currently in progress will enable us to understand the action mechanisms of EO.