Research Article
Proteomic Analysis of Sera from Common Variable Immunodeficiency Patients Undergoing Replacement Intravenous Immunoglobulin Therapy
Table 1
Clinical and laboratory data of healthy donors (C1–C12) and patients (Pt.1–Pt.3) contributing to serum samples for 2D-DIGE analysis.
| | ID | Sex | Serum sample |
Age (years) | Total protein level (g/dL) | Ig level (mg/dL) |
ERS (mm/1st h) |
CRP (mg/dL) |
Observed complications | | IgG | IgA | IgM |
| | C1 | M | | 32 | 7 | 1400 | 250 | 150 | 14 | 0.35 | — | | C2 | F | | 24 | 6.5 | 1100 | 200 | 80 | 14 | 0.33 | — | | C3 | M |
P1 | 33 | 7 | 1200 | 180 | 85 | 18 | 0.33 | — | | C4 | M | 29 | 6.8 | 1180 | 300 | 98 | 11 | 0.36 | — | | C5 | F | | 30 | 6.9 | 1110 | 100 | 100 | 7 | 0.4 | — | | C6 | M | | 32 | 7.2 | 1300 | 180 | 110 | 7 | 0.35 | — |
| | C7 | F | | 27 | 7 | 1280 | 270 | 70 | 4 | 0.30 | — | | C8 | F | | 31 | 6.6 | 900 | 260 | 90 | 20 | 0.5 | — | | C9 | M |
P2 | 30 | 6.8 | 980 | 360 | 180 | 2 | 0.5 | — | | C10 | F | 28 | 7.2 | 1160 | 220 | 150 | 4 | 0.35 | — | | C11 | F | | 26 | 6.8 | 990 | 230 | 90 | 2 | 0.35 | — | | C12 | F | | 27 | 7 | 1200 | 250 | 90 | 16 | 0.30 | — |
| | Pt. 1 | M | N1 | 33 | 6.2 | 7 | 6.1 | 10.5 | 9 | <0.31 | R, A | | I1 | 34 | 7.5 | 400 | 6.1 | 10 | 20 | 0.5 | R, A | | Pt. 2 | F | N2 | 12 | 5.9 | 171 | 6.1 | 4.1 | 7 | 1 | R | | I2 | 13 | 6.5 | 350 | 6.1 | 6 | 14 | 0.5 | R | | Pt. 3 | M | N3 | 59 | 6.3 | 273 | 13.9 | 38 | 18 | 1.79 | R, GI | | I3 | 60 | 7 | 380 | 15 | 50 | 24 | 1.4 | R, GI |
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ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; R: respiratory tract infections; GI: gastrointestinal tract infections; A: autoimmunity.
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