Bovine Model of Doxorubicin-Induced Cardiomyopathy

Table 3

Hemodynamics in doxorubicin-treated and normal calves.

	Normal^‡	Doxorubicin treated
CO (L/min)	8.1 ± 1.2	5.8 ± 2.4*
MAP (mm Hg)	90 ± 10	70 ± 17*
LAP (mm Hg)	14 ± 6	15 ± 9
LVPSP (mm Hg)	103 ± 9	88 ± 22
LVEDP (mm Hg)	16 ± 6	15 ±12
peak +dP/dt (mm Hg/s)	1252 ± 407	767 ± 222*
peak −dP/dt (mm Hg/s)	−2528 ± 866	−1135 ± 610*
LVEW (mm Hg·ml)	8758 ± 2441	6001 ± 2751
CAF (mL/min)	207 ± 138	77 ± 16

CO, cardiac output; MAP, mean arterial pressure; LAP, left atrial pressure; LV, left ventricular; PSP, peak systolic pressure; EDP, end diastolic pressure; EW, external work; CAF, coronary artery flow.
^‡normal calves from [18]. *𝑃<0.05 versus normal.