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Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 790871, 11 pages
Review Article

Extranodal NK/T-Cell Lymphoma: Toward the Identification of Clinical Molecular Targets

1INSERM U976, 75010 Paris, France
2Faculté des Sciences, Université Paris Diderot, 75013 Paris, France
3Immunologie, Oncologie, et Dermatologie, INSERM U976, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, Pavillon Bazin, 75475 Paris Cedex 10, France
4Department of Anatomic Pathology, Chang Gung Memorial Hospital, Gueishan 33305, Taiwan
5INSERM U955, 94010 Créteil, France
6Faculté de Médecine, Université Paris-Est Créteil, 94010 Créteil, France
7Groupe Henri-Mondor, Département de Pathologie, AP-HP, 94010 Créteil, France

Received 30 December 2010; Accepted 24 February 2011

Academic Editor: John E. Coligan

Copyright © 2011 Christian Schmitt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Extranodal natural killer (NK)/T-cell lymphoma of nasal type (NKTCL) is a malignant disorder of cytotoxic lymphocytes of NK or more rarely T cells associated with clonal Epstein-Barr virus infection. Extranodal NKTCL is rare in Western countries, but in Asia and Central and South America it can account for up to of non-Hodgkin's lymphomas. It is an aggressive neoplasm with very poor prognosis. Although the pathogenesis of extranodal NKTCL remains poorly understood, some insights have been gained in the recent years, especially from genome-wide studies. Based on our own experience and knowledge of the literature, we here review some of the genomic and functional pathway alterations observed in NKTCL that could provide a rationale for the development of innovative therapeutic strategies.