Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer

Table 1

Major CRC genes and syndromes.

Gene(s)	Syndrome	Inheritance	Lifetime CRC risk
APC	FAP	Autosomal dominant	100%
APC	AFAP	Autosomal dominant	69%
MUTYH	MAP	Autosomal recessive	80%
MLH1, MSH2, MSH6, PMS2, TACSTD1 (EpCAM)	LS	Autosomal dominant	80%
STK11	PJS	Autosomal dominant	39%
SMAD4 (DPC4), BMPR1A	JPS	Autosomal dominant	39%
PTEN	CS	Autosomal dominant	rare