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Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 852513, 10 pages
Review Article

Dampening Host Sensing and Avoiding Recognition in Pseudomonas aeruginosa Pneumonia

1Infections and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milano, Italy
2Dipartimento di Biologia Cellulare e dello Sviluppo, Sapienza-Università di Roma, 00185 Roma, Italy
3Istituto Pasteur-Fondazione Cenci Bolognetti, 00185 Roma, Italy

Received 15 December 2010; Accepted 9 May 2011

Academic Editor: Masao Kimoto

Copyright © 2011 Cristina Cigana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pseudomonas aeruginosa is an opportunistic pathogen and causes a wide range of acute and chronic infections. P. aeruginosa infections are kept in check by an effective immune surveillance in the healthy host, while any imbalance or defect in the normal immune response can manifest in disease. Invasive acute infection in the immunocompromised patients is mediated by potent extracellular and cell bound bacterial virulence factors. Life-threatening chronic infection in cystic fibrosis patients is maintained by pathogenic variants that contribute to evade detection and clearance by the immune system. Here, we reviewed the molecular basis of receptor-mediated recognition of P. aeruginosa and their role in initiating inflammation and the colonization. In addition, the consequence of the P. aeruginosa genetic adaptation for the antibacterial defence and the maintaining of chronic infection are discussed.