Emerging Role for Epithelial Polarity Proteins of the Crumbs Family as Potential Tumor Suppressors

<table>Crb proteins control Notch-dependent tissue growth. Crb proteins repress Notch (N) signaling in <i>Drosophila</i>, zebra fish, and mammalian cells. Different mechanisms account for the Crb-dependent inhibition of Notch signaling. <i>Drosophila</i> Crb and CRB2 inhibit <i>γ</i>-secretase activity. In addition, Crb limits Notch endocytosis, which is important for Notch signaling. Finally, the extracellular domain of Crb proteins binds to Notch and counteracts its activity.</table>

BioMed Research International

fig3

Figure 3

Figure 3: Emerging Role for Epithelial Polarity Proteins of the Crumbs Family as Potential Tumor Suppressors 