Methotrexate Toxicity in Growing Long Bones of Young Rats: A Model for Studying Cancer Chemotherapy-Induced Bone Growth Defects in Children
Figure 2
Mesenchymal stem cell commitment and effects of MTX chemotherapy in bone marrow adiposity. Multipotency of the mesenchymal stem cell (a), illustrated by the capacity to differentiate down a number of cell lineages. H & E stained bone marrow section taken from a control rat (b) and from an acute high-dose MTX-treated rat (c) showing adipocyte-rich bone marrow. (Images are from the authors’ own lab and have not been published previously.)
