Table 2: Different animal models in order to evaluate thrombus formation.

ReferenceMethod applied in order to induce plaque rupture and/or thrombus formationAnimal model

Reddick et al. [99]Forceps squeezing of the aortaApo E-/- mice
Gertz et al. [100]
Rekhter et al. [101]
Combination of double ballon injury and hypercholesterolemia and further angioplasty-induced plaque ruptureRabbits
Eitzman et al. [102]Photochemical reaction to previously formed atherosclerotic plaquesApo E-/- mice
Constantinides et al. [103]
Abela et al. [104]
Nakamura et al. [105]
Intraperitoneal injection of Russell’s viper venom* followed by i.v. injection of histamine (vasopressor), serotonin or angiotensin IIHypercholesterolemic rabbits
Rekhter et al. [106]Intracerebroventricular injection of corticotrophin-releasing factors (“stress hormone”)Apo E-/- mice
Heras et al. [107]Carotid angioplastyPig
Badimon et al. [52, 108]
Lassila et al. [65]
Thrombogenic effect of shear stress and atherosclerotic vessel components on the extracorporeal perfusion systemPig
Badimon et al. [36]
Fuster et al. [109, 110]
Von Willebrand factor deficiencyPigs with von Willebrand disease

*Procoagulant and endothelial toxin.