Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 917232, 7 pages
http://dx.doi.org/10.1155/2011/917232
Research Article

Simultaneous Identification and Quantification of Canrenone and 11-α-Hydroxy-Canrenone by LC-MS and HPLC-UVD

1School of Food and Biological Engineering, Jiangsu University, 301# Xuefu Road, Zhenjiang 212013, China
2PARCHN Sodium Isovitamin C Co., Ltd, Xingangshan Town, Dexing 334221, China
3Department of Respiratory Disease, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China

Received 24 August 2011; Accepted 20 September 2011

Academic Editor: Dobromir Dobrev

Copyright © 2011 Da-Ming Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Werner, M. Christine, B. Eber, E. Barbara et al., “Intoxication due to negative canrenone interference in digoxin drug monitoring,” The Lancet, vol. 354, no. 9185, pp. 1176–1177, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Marrs, S. Delagrave, and D. Murphy, “Novel approaches for discovering industrial enzymes,” Current Opinion in Microbiology, vol. 2, no. 3, pp. 241–245, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. C. L. Preisig, J. A. Laakso, U. M. Mocek, P. T. Wang, J. Baez, and G. Byng, “Biotransformations of the cardiovascular drugs mexrenone and canrenone,” Journal of Natural Products, vol. 66, no. 3, pp. 350–356, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Megges, J. Weiland, B. Undeutsch, H. Büchting, and R. Schön, “The nitration of canrenone with acetic anhydride/nitric acid,” Steroids, vol. 62, no. 12, pp. 762–766, 1997. View at Publisher · View at Google Scholar · View at Scopus
  5. E. G. McMahon, “Recent studies with eplerenone, a novel selective aldosterone receptor antagonist,” Current Opinion in Pharmacology, vol. 1, no. 2, pp. 190–196, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. E. D. Burgess, Y. Lacourciere, L. M. Ruilope-Urioste et al., “Long-term safety and efficacy of the selective aldosterone blocker eplerenone in patients with essential hypertension,” Clinical Therapeutics, vol. 25, no. 9, pp. 2388–2404, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. K. L. Davis and J. M. Nappi, “The cardiovascular effects of eplerenone, a selective aldosterone-receptor antagonist,” Clinical Therapeutics, vol. 25, no. 11, pp. 2647–2668, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. W. B. White, A. A. Carr, S. Krause, R. Jordan, B. Roniker, and W. Oigman, “Assessment of the novel selective aldosterone blocker eplerenone using ambulatory and clinical blood pressure in patients with systemic hypertension,” The American Journal of Cardiology, vol. 92, no. 1, pp. 38–42, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Gladiali, A. Gallotti, R. Vitali, and R. Gardi, “Facilitated reduction of 11-ketone in corticosteroid 17,21-diacetates,” Chemistry and Industry, vol. 24, pp. 982–983, 1977. View at Google Scholar · View at Scopus
  10. M. Nussium and F. Sondheimer, “New synthesis of 11-oxygenated steroids,” Chemistry & Industry, vol. 4, pp. 400–401, 1960. View at Google Scholar
  11. L. X. Du, S. J. Jia, and F. P. Lu, “Morphological changes of Rhizopus chinesis 12 in submerged culture and its relationship with antibiotic production,” Process Biochemistry, vol. 38, no. 12, pp. 1643–1646, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. A. J. Reyes, W. P. Leary, P. Crippa et al., “The aldosterone antagonist and facultative diuretic eplerenone: a critical review,” European Journal of Internal Medicine, vol. 16, no. 1, pp. 3–11, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Gharaee Fathabad, M. TabatabaeiYazdi, M. A. Faramarzi et al., “Biotransformation of Hydroeortisone by Neurospora crassa,” Journal of Sciences, Islamic Republic of Iran, vol. 17, no. 4, pp. 309–312, 2006. View at Google Scholar
  14. A. Romano, D. Romano, E. Ragg et al., “Steroid hydroxylations with Botryodiplodia malorum and Colletotrichum lini,” Steroids, vol. 71, no. 6, pp. 429–434, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. D. I. Sora, S. Udrescu, F. Albu, V. David, and A. Medvedovici, “Analytical issues in HPLC/MS/MS simultaneous assay of furosemide, spironolactone and canrenone in human plasma samples,” Journal of Pharmaceutical and Biomedical Analysis, vol. 52, no. 5, pp. 734–740, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. J. M. Sandall, J. S. Millership, P. S. Collier, and J. C. McElnay, “Development and validation of an HPLC method for the determination of spironolactone and its metabolites in paediatric plasma samples,” Journal of Chromatography B, vol. 839, no. 1-2, pp. 36–44, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Zhang and J. T. Stewart, “Liquid chromatographic determination of canrenone in human serum using solid-phase extraction,” Journal of Pharmaceutical and Biomedical Analysis, vol. 11, no. 11-12, pp. 1341–1344, 1993. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Jankowski, A. Skorek-Jankowska, and H. Lamparczyk, “Simultaneous determination of spironolactone and its metabolites in human plasma,” Journal of Pharmaceutical and Biomedical Analysis, vol. 14, no. 8-10, pp. 1359–1365, 1996. View at Publisher · View at Google Scholar · View at Scopus
  19. A. M. Kaukonen, P. Vuorela, H. Vuorela, and J. P. Mannermaa, “High-performance liquid chromatography methods for the separation and quantitation of spironolactone and its degradation products in aqueous formulations and of its metabolites in rat serum,” Journal of Chromatography A, vol. 797, no. 1-2, pp. 271–281, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Martin, A. I. Jimenez, O. Hernandez et al., “Simultaneous kinetic spectrophotome- tric determination of spironolactone and canrenone in urine using partial least-squares regression,” Talanta, vol. 49, no. 1, pp. 143–154, 1999. View at Google Scholar
  21. R. Herraez-Hernandez, E. Soriano-Vega, and P. Campins-Falco, “High-performance liquid chromatographic determination of spironolactone and its major metabolite canrenone in urine using ultraviolet detection and column-switching,” Journal of Chromatography B, vol. 658, no. 2, pp. 303–310, 1994. View at Publisher · View at Google Scholar · View at Scopus
  22. F. De Croo, W. Van den Bossche, and P. De Moerloose, “Simultaneous quantitative determination of butizide, potassium canrenoate and canrenone in tablets by high-performance liquid chromatography,” Journal of Chromatography A, vol. 354, pp. 367–373, 1986. View at Google Scholar · View at Scopus