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Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 968984, 6 pages
http://dx.doi.org/10.1155/2011/968984
Research Article

Antiobesity and Hypoglycaemic Effects of Aqueous Extract of Ibervillea sonorae in Mice Fed a High-Fat Diet with Fructose

1Department of Physiology, National School of Biological Sciences, National Polytechnic Institute, Prolongación de Carpio y Plan de Ayala s/n Colonia, Plutarco Elías Calles, Delegación Miguel Hidalgo, 11340 Mexico City, DF, Mexico
2Department of Pharmacy, National School of Biological Sciences, National Polytechnic Institute, Prolongación de Carpio y Plan de Ayala s/n Colonia, Plutarco Elías Calles, Delegación Miguel Hidalgo, 11340 Mexico City, DF, Mexico
3Department of Molecular Genetics, Interdisciplinary Research Center for Regional Integral Development, Sigma s/n Fraccionamiento 20 de Noviembre II, 34220 Durango, DGO, Mexico
4Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Avenida Wilfrido Massieu s/n, Esq. Manuel L. Stampa, Col. Unidad Profesional Adolfo López Mateos, Delegación Gustavo A. Madero, 07738 Ciudad de México, DF, Mexico

Received 15 June 2011; Revised 16 August 2011; Accepted 5 September 2011

Academic Editor: Vickram Ramkumar

Copyright © 2011 Fabiola Rivera-Ramírez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Obesity, type II diabetes, and hyperlipidaemia, which frequently coexist and are strongly associated with oxidative stress, increase the risk of cardiovascular disease. An increase in carbohydrate intake, especially of fructose, and a high-fat diet are both factors that contribute to the development of these metabolic disorders. In recent studies carried out in diabetic rats, authors reported that Ibervillea sonorae had hypoglycaemic activity; saponins and monoglycerides present in the plant could be responsible for the effects observed. In the present study, we determined the effects of an aqueous I. sonorae extract on a murine model of obesity and hyperglycaemia, induced by a high-calorie diet, and the relationship of these effects with hepatic oxidation. A high-fat diet over a period of 8 weeks induced weight gain in the mice and increased triglycerides and blood glucose levels. Simultaneous treatment with I. sonorae aqueous extracts, at doses of 100, 200, and 400 mg/kg, decreased triglycerides and glycaemia levels, prevented an increase in body weight in a dose-dependent manner, and decreased hepatic lipid oxidation at a dose of 200 mg/kg. These data suggest that the aqueous extract from I. sonorae root prevents obesity, dyslipidaemia, and hyperglycaemia induced by a hypercaloric diet; however, high doses may induce toxicity.