Protective Role of Cytotoxic T Lymphocytes in Filovirus Hemorrhagic Fever

Table 1

ZEBOV protein sequences recognized by murine CD8⁺ T cells. The table is adapted and expanded from [97].

ZEBOV protein	Epitope sequence	Amino acid position	Restriction	Protective^a	Reference
Glycoprotein	VSTGTGPGAGDFAFHK	141–155	H-2^d	Yes	[96, 98]
	LYDRLASTVI	161–169	H-2^d	NT	[25, 86, 98]
	EYLFEVDNL	231–239	H-2^d	NT	[25, 98]
	WIPYFGPAAEGIYTE	531–545	H-2^b	No	[86, 96]
	TELRTFSI	577–584	H-2^k	NT	[99]
Nucleoprotein	VYQVNNLEEIC	44–52	H-2^b	Yes	[37, 96, 100]
	GQFLFASL	148–156	H-2^b	Yes	[96]
	FLSFASLFL	150–159	HLA-A2.1	NT	[101]
	RLMRTNFLI	202–210	HLA-A2.1	NT	[101]
	SFKAALSSLA	279–287	H-2^d	Yes	[96, 100]
	FQQTNAMVT	388–396	H-2^b	NT	[100]
	KLTEAITAA	404–412	HLA-A2.1	NT	[101]
	DAVLYYHMM	663–671	H-2^b	Yes	[96]
VP24	KFINKLDALH	159–168	H-2^d	Yes
	NYNGLLSSI	171–179	H-2^d	Yes	[96]
	PGPAKFSLL	214–222	H-2^d	Yes
VP30	KFSKSQLSLLCETHLR	181–196	H-2^d	Yes
			H-2^b	Yes
	DLQSLIMFITAFLNI	231–245	H-2^d	Yes	[96]
			H-2^b	Yes
VP35	CDIENNPGL	45–53	H-2^b	Yes
	MVAKYDHL	138–145	H-2^b	Yes
	TVPQSVREAFNNL	190–202	H-2^d	Yes	[96]
	RNIMYDHL	225–323	H-2^b	Yes
	PGFGTAFHQLVQVICK	233–248	H-2^d	Yes
VP40	LRIGNQAFLQEFVLPP	150–165	H-2^b	Yes	[86, 96]
	AFLQEFVLPPVQLPQ	160–175	H-2^d	Yes	[96]
	YFTFDLTALK	171–180	H-2^d	Yes	[86, 96]
	TESPEKIQAI	232–241	H-2^d	Yes	[86, 96]

^aProtection from lethal challenge demonstrated by either peptide vaccination or by adoptive transfer experiments (Yes, >50% protection observed).
NT: Not tested.