Protective Role of Cytotoxic T Lymphocytes in Filovirus Hemorrhagic Fever

Table 2

MARV protein sequences recognized by murine H-2^d CD8⁺ T cells. Summary of data is from [102].

MARV protein	15-mer peptide sequence	Minimal peptide^a	Amino acid position	Adoptive transfer protection^b
Glycoprotein	FLISLILIQGTKNLP	ILIQGTKNL	11–19	50
	ILIQGTKNLPILEIA	QGTKNLPIL	14–22	20
	TCYNISVTDPSGKSL	VTDPSGKSL	97–105	NT
	SGKSLLLDPPTNIRD	LLLDPPTNI	105–113	0
	SPPPTPSSTAQHLVY	TPSSTAQHL	420–428	0
	GILLLLSIAVLIALS	LLLSIAVLI	659–667	100
	LSIAVLIALSCICRI	LSIAVLIAL	661–669	20
	LIALSCICRIFTKYI	IALSCICRI	667–675	40
Nucleoprotein	AINSGIDLGDLLEGG	NSGIDLGDL	43–51	80
	KFNTSPVAKYLRDAG	NTSPVAKYL	73–81	20
	EPHYSPLILALKTLE	HYSPLILAL	108–116	10
VP40	QHKNPNNGPLLAISG	KNPNNGPLL	218–226	40

^a9 mer peptide sequence derived from HLA binding predictions.
^bPercentage of animals protected from lethal challenge with mouse-adapted Marburg virus after adoptive transfer of CD8 lymphocytes specific for the 9-mer peptide sequences.
NT: not tested.