TY - JOUR
A2 - Chen, Su S.
AU - Zeng, Yili
AU - Huang, Qinmiao
AU - Zheng, Meizhu
AU - Guo, Jianxin
AU - Pan, Jingxin
PY - 2012
DA - 2012/03/12
TI - Effects of Reactive Nitrogen Scavengers on NK-Cell-Mediated Killing of K562 Cells
SP - 101737
VL - 2012
AB - This study explored the effects of reactive nitrogen metabolites (RNMS) on natural-killer- (NK-) cell-mediated killing of K562 cells and the influence of RNM scavengers, such as tiopronin (TIP), glutamylcysteinylglycine (GSH), and histamine dihydrochloride (DHT), on reversing the suppressing effect of RNM. We administered exogenous and endogenous RNM in the NK + K562 culture system and then added RNM scavengers. The concentrations of RNM, TNF-β and IFN-γ, and NK-cell cytotoxicity (NCC) and the percentage of living NK cells were then examined. We found that both exogenous and endogenous RNM caused the KIR to decrease (P<0.01); however, RNM scavengers such as TIP and GSH rescued this phenomenon dose dependently. In conclusion, our data suggests that RNM scavengers such as TIP and GSH enhance the antineoplasmic activity of NK cells.
SN - 2314-6133
UR - https://doi.org/10.1155/2012/101737
DO - 10.1155/2012/101737
JF - Journal of Biomedicine and Biotechnology
PB - Hindawi Publishing Corporation
KW -
ER -