Table of Contents Author Guidelines Submit a Manuscript
Review Article
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 103763, 3 pages
http://dx.doi.org/10.1155/2012/103763
Letter to the Editor

Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development: A Clinician’s Request for a More Integrated Approach

1Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
2Division of Pediatric Clinical Pharmacology, Children’s National Medical Center, Washington, DC, USA
3Departments of Pediatrics, Pharmacology, and Physiology, The School of Medicine and Health Sciences George Washington University, Washington, DC, USA
4Intensive Care Ward, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands

Received 8 November 2011; Accepted 28 December 2011

Copyright © 2012 Karel Allegaert et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Khalil and S. Läer, “Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 907461, 13 pages, 2011. View at Publisher · View at Google Scholar
  2. R. F. De Cock, C. Piana, E. H. Krekels, M. Danhof, K. Allegaert, and C. A. J. Knibbe, “The role of population PK-PD modelling in paediatric clinical research,” European Journal of Clinical Pharmacology, vol. 67, supplement 1, pp. S5–S16, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Läer, J. S. Barrett, and B. Meibohm, “The in silico child: using simulation to guide pediatric drug development and manage pediatric pharmacotherapy,” Journal of Clinical Pharmacology, vol. 49, no. 8, pp. 889–904, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. I. H. Bartelink, C. M. Rademaker, A. F. Schobben, and J. N. van den Anker, “Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations,” Clinical Pharmacokinetics, vol. 45, no. 11, pp. 1077–1097, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. T. N. Johnson and A. Rostami-Hodjegan, “Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice,” Paediatric Anaesthesia, vol. 21, no. 3, pp. 291–301, 2011. View at Publisher · View at Google Scholar
  6. K. Allegaert, R. Verbesselt, G. Naulaers et al., “Developmental pharmacology: neonates are not just small adults,” Acta Clinica Belgica, vol. 63, no. 1, pp. 16–24, 2008. View at Google Scholar · View at Scopus
  7. K. Allegaert, B. J. Anderson, J. N. van den Anker, S. Vanhaesebrouck, and F. de Zegher, “Renal drug clearance in preterm neonates: relation to prenatal growth,” Therapeutic Drug Monitoring, vol. 29, no. 3, pp. 284–291, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Claassen, S. Willmann, K. Thelen, K. Coboeken, K. Allegaert, and J. Lippert., “Physiology-based simulations of amikacin pharmacokinetics in preterm neonates,” PAGE, 19th meeting Berlin, abstract 1859, 2010, http://www.page-meeting.org/?abstract=1859.