Commercial Dengue Rapid Diagnostic Tests for Point-of-Care Application: Recent Evaluations and Future Needs?

Table 4

Description of selected recent diagnostic assessments of dengue RDT combining NS1 antigen, IgM, and IgG antibody results.

Assay	Study	Year	Location	Sample timing	Reference comparator	Analyte combination	Sensitivity (95% CI)	Specificity (95% CI)
	Tricou et al. [39]	2010	Vietnam	1–6 days illness	RT-PCR or paired MAC and GAC-ELISA	NS1/IgM	75.5 (69.6 – 80.8)	100 (93.8 – 100)
						NS1/IgM/IgG	83.7 (78.4 – 88.1)	97.9 (88.7 – 99.9)
	Wang and Sekaran [21]	2010	Malaysia	1–15 days	Virus isolation, RT-PCR, rising titer in a paired samples using MAC ELISA	NS1/IgM	88.7 (84.0 –93.3)	98.8 (96.3–100)
SD Dengue Duo Bioline	Osorio et al. [40]	2010	Colombia	Median 4; range 2–7 days illness	Viral culture, nested RT-PCR or paired MAC and GAC-ELISA	NS1/IgM	78.4 (72.4 –83.7)	91.3 (83.6–96.2)
						NS1/IgM/IgG	80.7 (75–85.7)	89.1 (81–94.7)
	Blacksell et al. [19]	2011	Sri Lanka	Median 5; IQR 2-7 days illness	AFRIMS MAC and GAC-ELISA paired samples	NS1/IgM	92.9 (83.9 –97.1)	88.8 (82.8–93.2
Panbio Early Rapid NS1 and Duo assay	Fry et al. [20]	2011	Malaysia	1–15 days; 70% ≤5 days illness	RT-PCR or paired MAC and GAC-ELISA	NS1/IgM	89.0 (85.2 – 92.8)	Not reported
						NS1/IgM/IgG	93.0	Not reported
	Blacksell et al. [19]	2011	Sri Lanka	Median 5; IQR 2–7 days illness	AFRIMS MAC and GAC-ELISA paired samples	NS1/IgM	89.9 (82.2–95.0)	75.0 (67.6–81.5)