New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy

Table 1

p53 mutations in commonly used human breast cancer cell lines.

Cell line	Exon	Codon	Type	Nucleotide change	Residue change
MDA-MB-231	8	280	Missense	AGA→AAA	Arg→Lys
CAMA-1	8	280	Missense	AGA→ACA	Arg→Thr
MDA-MB-468	8	273	Missense	CGT→CAT	Arg→His
BT-474	8	285	Missense	GAG→AAG	Glu→Lys
MDA-MB453s	8	266	Missense	GGA→GAA	Glu→Lys
BT-549	7	249	Missense	AGG→AGC	Arg→Ser
T-47D	6	194	Missense	CTT→TTT	Leu→Phe
Hs578T	5	157	Missense	GTC→TTC	Val→Phe
SK-BR-3	5	175	Missense	CGC→CAC	Arg→His
BT-20	5	132	Missense	AAG→CAG	Lys→Gln