Research Article

Topical Application Effect of the Isolectin Hydrogel (Cramoll 1,4) on Second-Degree Burns: Experimental Model

Figure 5

Epithelial tissue of rats in group 1 subjected to second-degree thermal burns. Masson’s trichrome staining. 100x Magnification. (a) Normal epithelial tissue with all skin appendages. (b) Animal presenting epithelial tissue with complete destruction of the dermis and epidermis showing exudates albumin/leukocyte/macrophage intense, necrosis, edema, and crust at the 7th day after injury induction. (c) Animal at the 14th day with tissue reepithelialization, moderate autolysis, moderate exudate albumin/leukocyte/macrophage, intense neovascularization, and discrete fibroblast proliferation with the presence of loose collagen and mild fibrosis. (d) Animal at the 21st day with incomplete tissue reepithelialization, mild exudate albumin/leukocyte/macrophage, moderate neovascularization, intense fibroblastic proliferation, and presence of dense collagen, not modeled and moderate fibrosis. (e) Animal at the 28th day with complete tissue epithelialization, exudate albumin/leukocyte/macrophage discrete in the epidermis, moderate fibroblastic proliferation, presence of modeled dense collagen mesh and moderate fibrosis. (f) Animal at the 35th day with complete reepithelialization, mild fibroblastic proliferation, and presence of modeled dense collagen mesh and moderate fibrosis.
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