Research Article
Association of Polymorphisms in Mitofusin-2 Gene with Type 2 Diabetes in Han Chinese
Table 3
Allele frequencies and genotype distributions of rs873458 and rs2878677 in MFN2 gene among stage 1 and stage 2 populations.
| | SNP | Genotype | Allele | | | T2D (%) | control (%) | | OR (95%CI) | | T2D (%) | control (%) | | OR (95% CI) |
| Stage 1 | rs873458 | | 555 | 638 | | | | | | | | | A/A | 50 (9.0) | 105 (16.5) | 0.0007/0.01 | 0.80 (0.67–0.95) | A | 382 (34.4) | 510 (40.0) | 0.005 | 0.79 (0.67–0.93) | | A/G | 282 (50.8) | 300 (47.0) | | | G | 728 (65.6) | 766 (60.0) | | | | G/G | 223 (40.2) | 233 (36.5) | | | | | | | | rs2878677 | | 549 | 643 | | | | | | | | | T/T | 124 (22.6) | 108 (16.8) | 0.03/0.02 | 0.83 (0.71–0.97) | T | 487 (44.4) | 503 (39.1) | 0.01 | 0.81 (0.68–0.95) | | C/T | 239 (43.5) | 287 (44.6) | | | C | 611 (55.6) | 783 (60.9) | | | | C/C | 186 (33.9) | 248 (38.6) | | | | | | | |
| Stage 2 | rs873458 | | 539 | 412 | | | | | | | | | A/A | 72 (13.4) | 58 (14.1) | 0.21/0.08 | 0.84 (0.69–1.02) | A | 386 (35.8) | 321 (39.0) | 0.16 | 0.87 (0.72–1.05) | | A/G | 242 (44.9) | 205 (49.8) | | | G | 692 (64.2) | 503 (61.0) | | | | G/G | 225 (41.7) | 149 (36.2) | | | | | | | | rs2878677 | | 545 | 417 | | | | | | | | | T/T | 135 (24.8) | 78 (18.7) | 0.05/0.02 | 0.80 (0.67–0.97) | T | 516 (47.8) | 348 (41.8) | 0.01 | 0.79 (0.65–0.94) | | C/T | 248 (45.5) | 192 (46.0) | | | C | 564 (52.2) | 484 (58.2) | | | | C/C | 162 (29.7) | 147 (35.3) | | | | | | | |
| Combinded | rs873458 | | 1094 | 1050 | | | | | | | | | A/A | 122 (11.2) | 163 (15.5) | 0.005/0.002 | 0.82 (0.72–0.93 ) | A | 768 (35.1) | 831 (39.6) | 0.002 | 0.83 (0.73–0.93) | | A/G | 524 (47.9) | 505 (48.1) | | | G | 1420 (64.9) | 1269 (60.4) | | | | G/G | 448 (41.0) | 382 (36.4) | | | | | | | | rs2878677 | | 1089 | 1059 | | | | | | | | | T/T | 259 (23.8) | 186 (17.6) | 0.0006/0.0004 | 0.81 (0.72–0.91) | T | 1003 (46.1) | 851 (40.2) | 0.0001 | 0.79 (0.69–0.89) | | C/T | 485 (44.5) | 479 (45.2) | | | C | 1183 (53.9) | 1267 (59.8) | | | | C/C | 345 (31.7) | 394 (37.2) | | | | | | | |
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had no adjustment, whereas Pc were adjusted for age, sex, and BMI.
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