The Emerging Role of PEDF in Stem Cell Biology

Table 1

Effects of PEDF on different types of stem cells.

Stem cell type	PEDF effect	Reference
Human embryonic stem cell	Proliferation, support, and survival	[22, 23]
Neural stem cell	Self-renewal	[31–33]
	Maintenance of multipotency
	Activation of cell division
	Antiapoptotic effects
Retinal stem cell	Self-renewal	[35, 37, 38]
	Cell expansion
	Inhibits migration of and induces apoptosis of endothelial cells
	Regression of CNV (at low doses)
	Development of neovascularisation (at high doses)