Table 1: Effects of PEDF on different types of stem cells.

Stem cell typePEDF effectReference

Human embryonic stem cellProliferation, support, and survival[22, 23]

Neural stem cellSelf-renewal [3133]
Maintenance of multipotency
Activation of cell division
Antiapoptotic effects

Retinal stem cellSelf-renewal [35, 37, 38]
Cell expansion
Inhibits migration of and induces apoptosis of endothelial cells
Regression of CNV (at low doses)
Development of neovascularisation (at high doses)