BioMed Research International / 2012 / Article / Tab 1

Research Article

TP53 Mutation, Epithelial-Mesenchymal Transition, and Stemlike Features in Breast Cancer Subtypes

Table 1

Genes entered in the study.

Official gene symbol Gene nameEntrez gene IDEnsembl genomic location

Apical junctional complexCDH1Cadherin 1, type 1, E-cadherin (epithelial)99916q22.1
CDH2Cadherin 2, type 1, N-cadherin (neuronal)100018q12.1
CLDN1Claudin 190763q28
CLDN2Claudin 29075Xq22.3
CLDN3Claudin 313657q11.23
CLDN4Claudin 413647q11.23
CLDN5Claudin 5712222q11.21
CLDN6Claudin 6907416p13.3
CLDN7Claudin 7136617p13.1
CLDN8Claudin 8907321q22.11
CLDN9Claudin 9908016p13.3
CLDN10Claudin 10907113q32.1
CLDN11Claudin 1150103q26.2
CLDN12Claudin 1290697q21.13
CLDN14Claudin 142356221q22.3
CLDN15Claudin 15241467q22.1
CLDN16Claudin 16106863q28
CLDN17Claudin 172628521q22.11
CLDN18Claudin 18512083q22.3
CLDN23Claudin 231370758p23.1
CTNNA1Catenin (cadherin-associated protein), alpha 114955q31.2
CTNNB1Catenin (cadherin-associated protein), beta 114993p22.1
CTNND1Catenin (cadherin-associated protein), delta 1150011q12.1
JAM2Junctional adhesion molecule 25849421q21.3
JAM3Junctional adhesion molecule 38370011q25
JUPJunction plakoglobin372817q21.2
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 192233p14.1
MARVELD2MARVEL domain containing 21535625q13.2
OCLNOccludin49505q13.2
PVRL1Poliovirus receptor-related 1 (herpesvirus entry mediator C)581811q23.3
PVRL2Poliovirus receptor-related 2 (herpesvirus entry mediator B)581919q13.32
PVRL3Poliovirus receptor-related 3259453q13.13
PVRL4Poliovirus receptor-related 4816071q23.3
SYMPKSymplekin818919q13.32
TJP1Tight junction protein 1 (zona occludens 1)708215q13.1
TJP2Tight junction protein 2 (zona occludens 2)94149q21.11
TJP3Tight junction protein 3 (zona occludens 3)2713419p13.3
VCLVinculin741410q22.2

ApoptosisBAXBCL2-associated X protein58119q13.33
BCL2B-cell CLL/lymphoma 259618q21.33
CASP2Caspase 2, apoptosis-related cysteine peptidase8357q34
ERBB2V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (avian)206417q12
MDM2Mdm2 p53 binding protein homolog (mouse)419312q15
TP53Tumor protein p53715717p13.1
TP53INP1Tumor protein p53 inducible nuclear protein 1942418q22.1
XIAPX-linked inhibitor of apoptosis331Xq25

Basal markersACTA1Actin, alpha 1, skeletal muscle581q42.13
CD44CD44 molecule (Indian blood group)96011p13
EGFREpidermal growth factor receptor19567p11.2
KRT5Keratin 5385212q13.13
KRT6AKeratin 6A385312q13.13
KRT6BKeratin 6B385412q13.13
KRT14Keratin 14386117q21.2
KRT17Keratin 17387217q21.2
TP63Tumor protein p6386263q28
VIMVimentin743110p13

Cell cycleCCNB3Cyclin B385417Xp11.22
CCND1Cyclin D159511q13.3
CCNE2Cyclin E291348q22.1
CDK2Cyclin-dependent kinase 2101712q13.2
CDK4Cyclin-dependent kinase 4101912q14.1
CDK6Cyclin-dependent kinase 610217q21.2
CDKN1ACyclin-dependent kinase inhibitor 1A (p21, Cip1)10266p21.2
CDKN1BCyclin-dependent kinase inhibitor 1B (p27, Kip1)102712p13.1
CDKN2ACyclin-dependent kinase inhibitor 2A (melanoma, p16, CDK4)10299p21.3
CDKN2BCyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)10309p21.3
CDKN2DCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)103219p13.2
GAS1Growth arrest-specific 126199q21.33
MKI67Antigen identified by monoclonal antibody Ki-67428810q26.2

Cell polarity complexesCRB1Crumbs homolog 1(Drosophila)234181q31.3
CRB3Crumbs homolog 3 (Drosophila)9235919p13.3
DLG1Discs, large homolog 1 (Drosophila)17393q29
DLG2Discs, large homolog 2 (Drosophila)174011q14.1
DLG3Discs, large homolog 3 (Drosophila)1741Xq13.1
DLG4Discs, large homolog 4 (Drosophila)174217p13.1
DLG5Discs, large homolog 5 (Drosophila)923110q22.3
INADLInaD-like (Drosophila)102071p31.3
MPP5Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)6439814q23.3
LLGL1Lethal giant larvae homolog 1 (Drosophila)399617p11.2
LLGL2Lethal giant larvae homolog 2 (Drosophila)399317q25.1
PARD3Par-3 partitioning defective 3 homolog (C. elegans)5628810p11.21
PARD3BPar-3 partitioning defective 3 homolog B (C. elegans)1175832q33.3
PARD6APar-6 partitioning defective 6 homolog alpha (C. elegans)5085516q22.1
PARD6BPar-6 partitioning defective 6 homolog beta (C. elegans)8461220q13.13
PARD6GPar-6 partitioning defective 6 homolog gamma (C. elegans)8455218q23
PRKCIProtein kinase C, iota55843q26.2
PRKCZProtein kinase C, zeta55901p36.33
SCRIBScribbled homolog (Drosophila)235138q24.3

Epithelial-mesenchymal transitionAKT1V-akt murine thymoma viral oncogene homolog 120714q32.33
AKT2V-akt murine thymoma viral oncogene homolog 220819q13.2
BMP1Bone morphogenetic protein 16498p21.3
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein339720q11.21
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein33982p25.1
ID3Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein33991p36.12
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein34006p22.3
SMAD2SMAD family member 2408718q21.1
SMAD3SMAD family member 3408815q22.33
SMAD4SMAD family member 4408918q21.2
SMAD5SMAD family member 540905q31.1
SMAD6SMAD family member 6409115q22.31
SMAD7SMAD family member 7409218q21.1
SMURF1SMAD specific E3 ubiquitin protein ligase 1571547q22.1
SMURF2SMAD specific E3 ubiquitin protein ligase 26475017q24.1
SNAI1Snail homolog 1 (Drosophila)661520q13.13
SNAI2Snail homolog 2 (Drosophila)65918q11.21
TCF3Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)692919p13.3
TGFBITransforming growth factor, beta-induced, 68 kDa70455q31.1
TGFBR1Transforming growth factor, beta receptor 170469q22.33
TGFBR2Transforming growth factor, beta receptor II70483p24.1
TGFBR3Transforming growth factor, beta receptor III70491p22.1
TGIF2TGFB-induced factor homeobox 26043620q11.23
TWIST1Twist homolog 1 (Drosophila)72917p21.1
TWIST2Twist homolog 2 (Drosophila)1175812q37.3
ZEB1Zinc finger E-box binding homeobox 1693510p11.22
ZEB2Zinc finger E-box binding homeobox 298392q22.3

Luminal markersCD24CD24 molecule1001339416q21
ESR1Estrogen receptor 120996q25.1
GATA3GATA binding protein 3262510p14
KRT7Keratin 7385512q13.13
KRT8Keratin 8385612q13.13
KRT18Keratin 18387512q13.13
KRT19Keratin 19388017q21.2
MUC1Mucin 1, cell surface associated45821q22
PGRProgesterone receptor524111q22.1

Metastasis-related genesCXCR4Chemokine (C-X-C motif) receptor 478522q22.1
CXCR5Chemokine (C-X-C motif) receptor 564311q23.3
MMP1Matrix metallopeptidase 1 (interstitial collagenase)431211q22.2
MMP2Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase)431316q12.2
MMP3Matrix metallopeptidase 3 (stromelysin 1, progelatinase)431411q22.2
MTA1Metastasis associated 1911214q32.33
MTA2Metastasis associated 1 family, member 2921911q12.3
MTA3Metastasis associated 1 family, member 3575042p21
PAK6P21 protein (Cdc42/Rac)-activated kinase 65692415q15.1
TIMP1TIMP metallopeptidase inhibitor 17076Xp11.23

Stemlike featuresABCG2ATP-binding cassette, sub-family G (WHITE),member 294294q22.1
ALDH1A1Aldehyde dehydrogenase 1 family, member A12169q21.13
ALDH1A3Aldehyde dehydrogenase 1 family, member A322015q26.3
BMI1BMI1 polycomb ring finger oncogene64810p12.2
JAG1Jagged 118220p12.2
JAG2Jagged 2371414q32.33
NANOGNanog homeobox7992312p13.31
NOTCH1Notch 148519q34.3
NOTCH2Notch homolog 2 (Drosophila)48531p12
NOTCH3Notch homolog 3 (Drosophila)485419p13.12
NOTCH4Notch homolog 4 (Drosophila)48556p21.32
NUMBNumb homolg (Drosophila)865014q24.3
PROM1Prominin 188424p15.32

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