CD73 Is Critical for the Resolution of Murine Colonic Inflammation

Figure 1

CD73^−/− mice develop more severe clinical signs of IBD than WT mice. (a) WT (circles) and CD73^−/− (squares) mice were given 3% DSS in drinking water and weighed daily for 10 days. Results are represented as % of initial weight (±SEM, summary of 5 experiments, 𝑛=26, *𝑃<0.05, **𝑃<0.01, ***𝑃<0.005). (b) Mean (±SEM, 𝑛=4, *𝑃<0.05, representative of 5 experiments) colonic blood score is displayed (0 = no blood in colon; 1 = blood in 25% of colon; 2 = blood in 50% of colon; 3 = blood in 75% of colon; 4 = blood in 100% of colon). (c) Mean (±SEM, 𝑛=4, *𝑃<0.05, representative of 5 experiments) colon length (cm) is displayed, along with (d) a representative photograph.

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