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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 285938, 6 pages
Research Article

Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy: A Microscopic Study Contrasted with the Hormonal Assays

1Departamento de Nutrição, Universidade Federal de São Paulo (UNIFESP-EPM), Rua Marselhesa, 630, Vila Clementino, 04020-620 São Paulo, SP, Brazil
2Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP-EPM), Rua Napoleão de Barros, 295, Vila Clementino, 04024-002 São Paulo, SP, Brazil
3Departmento de Biología, Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista (UNESP), Rua Cristóvão Colombo 2265, Jardim Nazareth, 15054-000 São José do Rio Preto, SP, Brazil
4Departamento de Morfologia, Universidade Federal de Goiás, Campus II Samambaia, Caixa Posta 131, 74001-970 Goiânia, GO, Brazil

Received 30 December 2011; Accepted 16 June 2012

Academic Editor: Oreste Gualillo

Copyright © 2012 Daniel P. Venâncio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy. Microscopic analysis of the prostate reveals that morphology of this gland was altered after 96 h of PSD and 21 days of SR, with the most important alterations occurring in the epithelium and stroma in the course of both procedures compared with the control group. Both 96 h PSD and 21-day SR rats showed lower serum testosterone and higher corticosterone levels than control rats. The significance of our result referring to the sleep deprivation was responsible for deep morphological alterations in ventral prostate tissue, like to castration microscopic modifications. This result is due to the marked alterations in hormonal status caused by PSD and SR.