In Vivo Clearance of Alpha-1 Acid Glycoprotein Is Influenced by the Extent of Its N-Linked Glycosylation and by Its Interaction with the Vessel Wall
Table 1
Pharmacokinetic parameters relating to AGP clearance in rabbits.
Form of AGP
pdAGP
PNGase-AGP (PNGase-treated)
rAGP N(5)Q
Area under the curve (AUC 0-∞) (in pmol-hr/mL)
11 ± 1
5.8 ± 0.9
0.74 ± 0.07***
Mean residence time (MRT; in hr)
73 ± 6
57 ± 3
23 ± 6***
Volume of distribution (Vdiss; in mL/kg)
190 ± 20
700 ± 100***
6000 ± 1000***
Steady state volume of distribution (Vss; in mL/kg)
160 ± 20
550 ± 90***
2000 ± 500***
Clearance (CL; mL/hr/kg)
2.23 ± 0.03
11 ± 2***
100 ± 10***
Half-life calculated from Vdiss and CL (hours)
58 ± 4
50 ± 3
42 ± 9**
The mean ± the standard deviation is shown (). Derivatives of AGP were compared to the corresponding AGP value using one-way ANOVA with Tukey’s post-test; **indicates , ***indicates .
