Conditioned Medium from Adipose Tissue-Derived Mesenchymal Stem Cells Induces CD4+FOXP3+ Cells and Increases IL-10 Secretion

Table 1

The effect of AT-MSCs conditioned medium on the percentage values of CD4+FoxP3+ T lymphocytes in cultures of T helper cells obtained from different donors. The data from all subjects tested revealed the stable tendency towards an increase of CD4+CD25+FoxP3+ and CD4+CD25−FoxP3+ cell numbers in the presence of AT-MSCs conditioned medium compared with the respective control cultures.

	CD4+CD25+FoxP3+			CD4+CD25−FoxP3+
	w/o AT-MSCs c.m.	With AT-MSCs c.m.		w/o AT-MSCs c.m.	With AT-MSCs c.m.
Donor 1	3.45%	4.42%		2.12%	4.12%
Donor 2	2.19%	2.91%		1.72%	2.37%
Donor 3	5.04%	5.52%		1.74%	2.26%
Donor 4	1.47%	2.48%		2.84%	3.06%
Donor 5	3.95%	5.73%		1.88%	2.25%
Donor 6	2.87%	4.55%		1.01%	1.95%
Donor 7	5.80%	7.65%		2.84%	4.32%
Donor 8	5.69%	5.81%		3.13%	3.78%
Donor 9	1.30%	3.33%		1.41%	2.32%
Donor 10	1.77%	2.03%		0.7%	1.10%
Donor 11	1.90%	5.39%		0.7%	0.92%
Donor 12	2.92%	5.06%		1.6%	1.7%