Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 301931, 8 pages
http://dx.doi.org/10.1155/2012/301931
Research Article

Enhancement of Recombinant Human Endostatin on the Radiosensitivity of Human Pulmonary Adenocarcinoma A549 Cells and Its Mechanism

Department of Radiology, Lianyungang First People's Hospital, Jiangsu, Lianyungang 222002, China

Received 26 January 2012; Accepted 27 April 2012

Academic Editor: Andre Van Wijnen

Copyright © 2012 Xiao-dong Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Baumann, G. Stamatis, and M. Thomas, “Therapy of localized non-small cell lung cancer(take home messages),” Lung Cancer, vol. 33, supplement 1, pp. S47–S49, 2001. View at Google Scholar
  2. C. H. Ling, C. Ji, and Y. B. Chen, “Combined effects of endostatin gene transfer and ionizing radiation on lung adenocarcinomamodel of A549 cells,” Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 27, no. 10, pp. 683–686, 2004. View at Google Scholar
  3. X. Luo, M. L. Andres, T. M. Timiryasova, I. Fodor, J. M. Slater, and D. S. Gridley, “Radiation-enhanced endostatin gene expression and effects of combination treatment,” Technology in Cancer Research and Treatment, vol. 4, no. 2, pp. 193–202, 2005. View at Google Scholar · View at Scopus
  4. R. K. Jain, “Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy,” Science, vol. 307, no. 5706, pp. 58–62, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. F. Winkler, S. V. Kozin, R. T. Tong et al., “Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases,” Cancer Cell, vol. 6, no. 6, pp. 553–563, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. O. Casanovas, “Cancer: limitations of therapies exposed,” Nature, vol. 484, no. 7392, pp. 44–46, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. M. Kim, J. W. Jang, O. H. Lee et al., “Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase 2,” Cancer Research, vol. 60, no. 19, pp. 5410–5413, 2000. View at Google Scholar · View at Scopus
  8. D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Global cancer statistics, 2002,” CA-A Cancer Journal for Clinicians, vol. 55, no. 2, pp. 74–108, 2005. View at Google Scholar · View at Scopus
  9. W. K. De Jong, M. Schaapveld, J. L. G. Blaauwgeers, and H. J. M. Groen, “Pulmonary tumours in the Netherlands: focus on temporal trends in histology and stage and on rare tumours,” Thorax, vol. 63, no. 12, pp. 1096–1102, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. E. L. Gressen and W. J. Curran, “Hyperfractionated radiotherapy for lung cancer,” Current oncology reports, vol. 2, no. 1, pp. 71–75, 2000. View at Google Scholar · View at Scopus
  11. M. S. O'Reilly, T. Boehm, Y. Shing et al., “Endostatin: an endogenous inhibitor of angiogenesis and tumor growth,” Cell, vol. 88, no. 2, pp. 277–285, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. R. K. Jain, “Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy,” Science, vol. 307, no. 5706, pp. 58–62, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Winkler, S. V. Kozin, R. T. Tong et al., “Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases,” Cancer Cell, vol. 6, no. 6, pp. 553–563, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Huang and L. Chen, “Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma,” Journal of Cancer Research and Clinical Oncology, vol. 136, no. 8, pp. 1201–1211, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Nyberg, P. Heikkilä, T. Sorsa et al., “Endostatin inhibits human tongue carcinoma cell invasion and intravasation and blocks the activation of matrix metalloprotease-2, -9, and -13,” The Journal of Biological Chemistry, vol. 278, no. 25, pp. 22404–22411, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. R. F. Wilson, M. A. Morse, P. Pei et al., “Endostatin inhibits migration and invasion of head and neck squamous cell carcinoma cells,” Anticancer Research, vol. 23, no. 2, pp. 1289–1295, 2003. View at Google Scholar · View at Scopus
  17. F. Dkhissi, H. Lu, C. Soria et al., “Endostatin exhibits a direct antitumor effect in addition to its antiangiogenic activity in colon cancer cells,” Human Gene Therapy, vol. 14, no. 10, pp. 997–1008, 2003. View at Publisher · View at Google Scholar · View at Scopus