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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 320495, 7 pages
http://dx.doi.org/10.1155/2012/320495
Review Article

The CD39-Adenosinergic Axis in the Pathogenesis of Immune and Nonimmune Diabetes

1Immunology Research Centre, St. Vincent's Hospital Melbourne, Fitzroy 3065, Australia
2Department of Medicine, University of Melbourne, Parkville 3010, Australia

Received 18 May 2012; Accepted 27 July 2012

Academic Editor: John Stagg

Copyright © 2012 Joanne S. J. Chia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetes mellitus encompasses two distinct disease processes: autoimmune Type 1 (T1D) and nonimmune Type 2 (T2D) diabetes. Despite the disparate aetiologies, the disease phenotype of hyperglycemia and the associated complications are similar. In this paper, we discuss the role of the CD39-adenosinergic axis in the pathogenesis of both T1D and T2D, with particular emphasis on the role of CD39 and CD73.